Calcineurin Inhibitor and Nonsteroidal Anti-inflammatory Drug Interaction: Implications of Changes in Renal Function Associated With Concurrent Use - ON DEMAND

ACCP Virtual Journal Club Webinars

Live Session: Wednesday, March 13, 2019 from 2:00-3:00pm ET

On Demand: March 13, 2019 through March 13, 2022

Why is this webinar important to you? 

Please join us as we discuss the drug interaction between calcineurin inhibitors (CNI) and non-steroidal anti-inflammatory drugs (NSAID) in hospitalized transplant recipients. Although the renal adverse effects of this drug interaction are widely accepted, evidence supporting them are limited. Additionally, the magnitude of adverse renal effects stemming from this drug interaction are unclear. In order to elucidate more information, a recently published, retroactive research study was conducted. This investigation set out to systematically evaluate the impact and magnitude of changes in renal function in hospitalized transplant recipients exposed to both agents. Changes in serum creatinine, specifically those sufficient to cause acute kidney injury (AKI), were analyzed throughout each patient's hospital stay. This data was used to evaluate the incidence of AKI as well as maximal changes in serum creatinine following concomitant use. Join us as we discuss the results of this investigation and provide more detailed evidence supporting this drug interaction.

Target Audience

Interprofessional team of Physicians, Pharmacists, PhDs, Nurse Practitioners and Physician Assistants. 

Learning Objectives

After completing this activity, the learner will be able to:

1) Characterize the effect of CNI and NSAID therapy on serum creatinine;
2) Define AKI occurrence potential within the NSAID class;
3) Identify therapeutic recommendations for the combined use of CNIs and NSAIDs in hospitalized transplant patients;
4) Define changes in excretory renal function between experimental groups.

Requirements to Receive Credit

In order to receive continuing medical education (CME) or continuing pharmacy education (CPE) credit, the learner must register for the educational activity, study the provided journal article, attend the Live webinar or view the On Demand webinar, complete the online learning Self-assessment Post-test as well as the online course Evaluation and CME/CPE Certificate. Credits and CME/CPE Certificates must be claimed within thirty (30) days of completing the webinar, Post-test and Evaluation. Contact CE@ACCP1.org with any questions.

See CE Info in handouts tab for more information on CME and CPE credits.