2021 ACCP Virtual Journal Club Webinar-December | Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics-LIVE

Includes a Live Event on 12/08/2021 at 2:00 PM (EST)

2021 ACCP Virtual Journal Club Webinar: Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics - LIVE

Live webinar: December 8, 2021 from 2:00 - 3:00 PM ET 

On-demand webinar recording: December 8, 2021 to December 8, 2024

Why is this article important to your practice? 

Cobimetinib is a kinase inhibitor indicated for use in combination with vemurafenib for treatment of unresectable/metastatic melanoma with specific BRAF mutations. Cobimetinib is extensively metabolized in liver; thus, patients with hepatic impairment (HI) might have increased cobimetinib exposure. By attending this educational activity, you will learn about the impact of HI on the pharmacokinetics (PK) and safety of cobimetinib. 

Target Audience:

Interprofessional team of Physicians, Pharmacists, PhDs, Nurse Practitioners and Physician Assistants.

Sravanthi Cheeti, MS,

Scientist

Genentech Inc

Sravanthi Cheetiā€™s focus is on clinical drug development, specifically on clinical pharmacology, which includes understanding the pharmacokinetics and pharmacodynamics of a drug in humans and how these and other factors relate to the clinical efficacy and safety of the drug. She has 14 years of industrial experience in clinical pharmacology. During this time, she has supported several oncology and neuroscience programs. She has developed clinical pharmacology strategies, including dose/regimen selection for Phase I - III studies and clinical pharmacology assessments to inform clinical protocols and label updates.She played a key role in determining appropriate dose and dose adjustments for special populations (e.g. pediatric, organ impairment, ethnicity, etc.), drug-drug interaction assessments, material bridging, and food effect assessments.

Key:

Complete
Failed
Available
Locked
Article
Open to download resource.
Open to download resource.
Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics
12/08/2021 at 2:00 PM (EST)   |  60 minutes
12/08/2021 at 2:00 PM (EST)   |  60 minutes
Virtual Journal Club-December - Evaluation
5 Questions