2022 ACCP Virtual Journal Club March | Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment-ON DEMAND
Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment-ON DEMAND
ACCP Virtual Journal Club Webinars
On Demand: March 16, 2022 to March 16, 2025
See Handouts tab for Continuing Education information on CME and CPE credits.
Why is this webinar important to you?
Brexpiprazole is an oral antipsychotic agent indicated for use in patients with schizophrenia or as adjunctive treatment for major depressive disorder.
As obesity (body mass index ≥35 kg/m2) has the potential to affect drug pharmacokinetics and is a common comorbidity of both schizophrenia
and major depressive disorder, it is important to understand changes in brexpiprazole disposition in this population. This study uses a whole-body
physiologically-based pharmacokinetic (PBPK) model to compare the pharmacokinetics of brexpiprazole in obese and normal-weight (body mass index 18-
25 kg/m2) individuals known to be cytochrome P450 2D6 extensive metabolizers and poor metabolizers (PMs).
Physicians, Pharmacists, PhDs and Physician Assistants.
After completing this activity, the learner will be able to:
1) Explain the relationship between obesity, Brexpiprazole pharmacokinetics and clinical outcome;
2) Articulate the relationship between PMs, Brexpiprazole dosing and clinical outcome;
3) Learn about the PBPK model.
To receive credit, learners must attend the complete live webinar or view the complete on-demand webinar; complete a post-course assessment and evaluation.
Christina Chow, PhD
Head of Research
Emerald Lake Safety
Christina Chow has spent her entire career in pharmacology research. At Emerald Lake Safety, Dr. Chow leads collaborations with external scholars and researchers on clinical studies and scientific analyses. Before joining the ELS team, Dr. Chow was a Postdoctoral Fellow at the Robert H. Lurie Comprehensive Cancer Center at Northwestern University and a former Visiting Research Specialist at the Research Center for Advanced Science and Technology at The University of Tokyo. Dr. Chow received her PhD in Pharmacology at the University of Illinois at Chicago.
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