This webinar addresses gaps in foundational training on core Exposure–Response (E-R) principles relevant to drug development and clinical pharmacology practice. The presentation will explore practical steps to develop credible, fit-for-purpose E-R models aligned with best practices across the drug development continuum. Learners who complete this activity will enhance their knowledge of foundational E-R concepts, strengthening problem solving and critical thinking skills that can be directly applied to clinical pharmacology and regulatory decision-making settings.