Learners completing this activity will be able to describe the fundamental principles and emerging applications of Organ-on-a-Chip (OoC) technology in clinical pharmacology and drug development. This activity will explore how microengineered systems replicate aspects of human organ structure and function to provide human-relevant models for investigating drug disposition and response. Faculty will discuss applications of OoC systems in preclinical and early-phase drug development, including the evaluation of absorption, distribution, metabolism and excretion (ADME), prediction of metabolic pathways and drug clearance and assessment of enzyme- and transporter-mediated drug–drug interactions. The activity will also examine how OoC-generated data can support pharmacokinetic/pharmacodynamic (PK/PD) analyses, physiologically based pharmacokinetic (PBPK) modeling and translational decision-making, including the prediction of human drug exposure and first-in-human dose selection. Current limitations and challenges related to validation, reproducibility and standardization will also be addressed.

Microaggressions are subtle, often unintentional, comments or behaviors that convey prejudiced or dismissive messages toward individuals including researchers and clinical scientists. While they may seem minor or harmless to the person delivering them, they can have a significant cumulative impact on the recipient’s mental and emotional well-being. The aim of this webinar is to get participants to recognize and understand the impact of microaggressions—subtle comments or behaviors that reinforce bias. Learners will be provided with practical tools for identifying microaggressions in real-time and strategies for interrupting them constructively. Attendees will leave with greater awareness of their own default roles and actionable strategies to foster personal agency, healthy boundaries, and supportive communication.