2023 ACCP Virtual Journal Club Webinar: A Review on Drug-Induced Nephrotoxicity: Pathophysiological Mechanisms, Drug Classes, Clinical Management and Recent Advances in Mathematical Modeling and Simulation Approaches | ON DEMAND

On Demand webinar recording: February 16, 2023 to February 16, 2026

Why is this article important to your practice? 

Drug-induced nephrotoxicity (DIN) is a major clinical challenge for a variety of marketed drugs belonging to various therapeutic areas.  Successful clinical prevention of DIN requires prior knowledge of drug’s mechanism of action coupled with pathogenic mechanisms of renal injury as well as patient- and drug-related risk factors. Recently, significant innovative advances in the identification of novel early biomarkers for DIN have been made. However, they are not beyond limitations. In such scenarios, mathematical modeling and simulation (M&S) may be used as a robust tool to understand and predict DIN in a clinical setting. This presentation highlights some of the recent advancements in mathematical M&S approaches for DIN. An example of the utility of multiscale and translational M&S for combinatorial effects of a DIN with a proposed preventive therapeutic will be showcased.

Target Audience:

 Physicians, Pharmacists, PhDs.

Learning Objectives

After completing this activity, the learner will be able to:

1) Review the various mechanisms of DIN and highlight the associated classes of nephrotoxic drugs;

2) Describe the current approach to prevention, diagnosis and management of drug-induced nephrotoxicity;

3) Summarize recent advances in the role of mathematical M&S in DIN.