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  • 2019 ACCP Journal of Clinical Pharmacology Journal CE | Monthly CE Offerings

    Contains 28 Component(s), Medical Credits Offered

    The American College of Clinical Pharmacology® monthly journal article continuing education offerings from The Journal of Clinical Pharmacology.

    Registration and Pricing

    The American College of Clinical Pharmacology® (ACCP) offers a monthly article from the The Journal of Clinical Pharmacology (JCP) for continuing education credit. See the CE Info tab for more information on credits. The ACCP JCP Journal CE articles are priced and packaged for January through December of the same calendar year. Packages are available at no cost to ACCP Members and $75/calendar year to Non-members. Once registered, learners have access to all of the Journal CE articles for the calendar year as the articles are released.

    To register, log into your ACCP online profile and then register by clicking the green Register button at the top right. Follow the online prompts to complete the registration process and to receive your registration confirmation. If you do not have an ACCP profile, one must be created before you can register for the Journal CE articles. If you do not know if you have a profile, please contact KLevy@ACCP1.org for further information to avoid creating duplicate profiles. Please address all other questions to CE@ACCP1.org.

    Requirements for Credits

    All requirements for claiming CE credits are listed in the CE Info tab. Continuing education credits and certificates must be claimed within 30-days of completing the monthly article offering. Continuing Pharmacy Education (CPE) data is uploaded into the CPE Monitor at the end of each month. The pharmacist's NABP# and MMDD of birth must be updated into their ACCP Profile or emailed to CE@ACCP1.org in order to have CPE credits automatically uploaded to the CPE Monitor.

    CE Expiration 12/31/2021




     

  • 2019 ACCP Virtual Journal Club April | Accelerating Drug Development in Pediatric Oncology With the Clinical Pharmacology Storehouse - ON DEMAND

    Contains 5 Component(s), Medical Credits Offered

    Presented by: Mohamad Shebley, PhD, Director & Volwiler Research Fellow, AbbVie Inc, Clinical Pharmacology & Pharmacometrics

    Accelerating Drug Development in Pediatric Oncology With the Clinical Pharmacology Storehouse - ON DEMAND

    ACCP Virtual Journal Club Webinars

    Live Session: Wednesday, April 24, 2019 from 2:00-3:00 PM EDT

    On Demand: April 24, 2019 to April 24, 2022

    See Handouts tab for Continuing Education information on CME and CPE credits.


  • 2016 ACCP Therapeutic Dilemmas August | Managing Chronic Pain: Current Challenges for Ensuring Safe and Efficacious Opioid Use

    Contains 4 Component(s), Medical Credits Offered

    Presented by Gary A. Walco, PhD, ABPP Professor of Anesthesiology and Pain Medicine, Adjunct Professor of Pediatrics and Psychiatry, Univ of Washington School of Medicine; Director of Pain Medicine, Seattle Children’s Hospital

    ACCP Therapeutic Dilemmas:Managing Chronic Pain: Current challenges for Ensuring Safe and Efficacious Opioid Use

    Presented by Gary A. Walco, PhD, ABPP Professor of Anesthesiology and Pain Medicine, Adjunct Professor of Pediatrics and Psychiatry, Univ of Washington School of Medicine; Director of Pain Medicine, Seattle Children's Hospital

    Why is this topic important to your practice?
    The Centers for Disease Control and Prevention (CDC) have recently released 'best practice' guidelines for opioid prescribing in an effort to address the extensive and often deadly consequences of opioid misuse. However, these guidelines exclude those patients <18 years of age. This creates a therapeutic dilemma by leaving the pediatric population on the outside of a highly relevant and critical healthcare discussion. Additionally, this may put children in a position whereby opioid prescribing criteria recommended for adults is extrapolated to children with unknown consequences.

    This therapeutic dilemma is rooted in a circumstance all too common within the pediatric community. Specifically, that pediatric data regarding opioid use for chronic pain management are limited to such a degree that sufficient evidence is not available to guide strong recommendations. Nonetheless, opioid prescribing is a topic of enormous importance for the pediatric population. Directly and indirectly, opioid prescribing patterns and consensus guidelines will affect the health of children. Certainly, new guidelines pertaining to adults may offer benefit to pediatric patients via less accidental access or misuse of opioids. Yet, a more comprehensive approach to understanding the safe and effective clinical use of opioids among patients experiencing chronic pain who are <18 years of age is needed.

    Target Audience
    This webinar is intended for pharmacologists, pharmacists, clinicians or graduate/postgraduate trainees wishing to better understand the implications of consensus guidelines on opioid prescribing practices across a variety of patient populations, including pediatric. Practical aspects and consequences of integrating recent professional guidelines related to opioid prescribing into clinical practice and barriers to safe and efficacious opioid prescribing. This webinar is also suitable for pharmacology/biomedical graduate or medical students who are interested in clinical pharmacology or integrative medicine. Additionally, individuals who are likely to be involved in the facilitating patient care such as physician assistants, nursing and pharmacy professionals may also benefit from this webinar.

    Goal and Objectives
    The goal of this CE activity is:
    With the release of the CDC's consensus statement directed to change adult opioid prescribing practices and ameliorate the current epidemic of addiction, misuse, and overdose in the United States, it is imperative that this discussion be extended to young patients. To this point, this webinar will facilitate improved understanding of 'best practices' for opioid prescribing among pediatric patients to maximize safety and efficacy. Additionally, this webinar will identify patient and environmental factors that may increase the risk for poor treatment outcomes or adverse consequences related to opioid use. This webinar will discuss the role of opioid use in clinical scenarios, as a broader part of individualized medicine.

    After completing this activity the learner will:

    1. Understand current research concerning and clinical evidence behind safe and effective opioid prescribing in different populations
    2. Identify opioid prescribing patterns that can lead to ineffective pain management, hospitalization, and death
    3. Identify patients who may be at high risk for poor outcomes with opioid therapy
    4. Identify alternatives to opioid therapy for managing chronic pain
    5. Learn the latest information regarding opioid use, misuse, addiction, and death
    6. Better understand current recommendations and how they apply across different populations to lessen the epidemic of opioid misuse and abuse


    Recorded August 17, 2016





    Gary A. Walco, PhD, ABPP is a Professor of Anesthesiology (adjunct in Pediatrics and Psychiatry) at the Univ of Washington School of Medicine and the Director of Pain Medicine at Seattle Children's Hosp. He has conducted multiple studies on pain management and assessment in children and has published an array of journal articles, book chapters and books, including a text he co-edited, Pain in Children: A Practical Guide for Primary Care. Dr. Walco was the founder of the Special Interest Group on Pain in Infants, Children and Adolescents for the American Pain Society and was the 2003 recipient of the Jeffrey Lawson Award for Advocacy in Children's Pain Relief. He also received the Lee Salk Distinguished Service Award for outstanding contributions to pediatric psychology from the American Psychological Association in 2006. Dr. Walco chaired the task force responsible for the joint American Academy of Pediatrics policy statement on the assessment and management of acute pain in children, is the immediate past chair of the Pain Committee for the Children's Arthritis and Rheumatology Research Alliance and was on the core committee for Palliative Care in the Children's Oncology Group. He is the past president of the special interest group on Pain in Childhood of the International Association for the Study of Pain. Dr. Walco currently sits on the editorial board of Pain, the Journal of Pain the Clinical Journal of Pain (for which he is a past associate editor). He was an invited member of the Neonatal Pain Research Initiative (NICHD, FDA), the Pediatric Analgesia Trials workshop (FDA) and various IMMPACT panels, typically representing a pediatric perspective. Dr. Walco has served as a consultant to a number of pharmaceutical firms on analgesic trials for children, is currently a special government employee, having served on the United States Food & Drug Administration's Anesthetic and Life Support Drugs Advisory Committee.He is the founder and first chair of the Pediatric Research Network for Pain, an international collaborative to conduct pain research in children, and co-chairs the Pediatric Pain Research Consortium of ACTTION, a public-private partnership with the United States Food & Drug Administration.

    CPE 1 Contact Hours
    Live UAN Number: 0238-0000-16-036-L05-P
    On-Demand UAN Number: 0238-0000-16-037-H05-P   Expires 8/17/2019

    Knowledge - Based Activity

    imageACPE Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.

    imageACCME Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Designation Statement

    The American College of Clinical Pharmacology designates this live activity for 1 AMA PRA Category 1TM credit. Physicians should only claim credit commensurate with the extent of the participation in the activity.

    In order to receive CE credit, the learner must score 75% or better on the online post-test and must complete an online evaluation.

    Presenter: Gary A. Walco, PhD, ABPP Professor of Anesthesiology and Pain Medicine, Adjunct Professor of Pediatrics and Psychiatry, University of Washington School of Medicine; Director of Pain Medicine, Seattle Children's Hospital. Disclosure: consultation to Pfizer Pharmaceuitcals.

    Moderators: Catherine Sherwin, PhD, MS, FCP and Jonathan Constance, PhD, of the University of Utah School of Medicine, who developed the continuing education portion of this activity (target audience, goals and objectives and questions with solutions) have nothing to disclose.

  • 2016 ACCP Therapeutic Dilemmas November | Immune Senescence: What Vaccines Do We Need to Protect Senior Citizens From Infections?

    Contains 4 Component(s), Medical Credits Offered

    Presented by Elena Yu Enioutina, MD, PhD

    THERAPEUTIC DILEMMAS: Immune Senescence: What Vaccines Do We Need to Protect Senior Citizens From Infections?

    Presented by Elena Yu Enioutina, MD, PhD

    Recorded November 9, 2016

    Why is this topic important to your practice?
    Among older adults immune competency can vary widely and declines in an age-dependent manner, termed immune senescence. Changes in immune function, which can occur both with the innate and adaptive arms of the immune system, have implications for therapies based on immune system function, such as vaccines. While the Centers for Disease Control and Prevention (CDC) have recommended an immunization schedule for older adults, the overall endeavor to prevent infectious disease using vaccines among the immune senescent represents a therapeutic dilemma. An understanding of precise mechanisms of immune senescence will help to address vaccine design for elderly patients and/or immune interventions that could help to improve responsiveness to vaccinations and ultimately prevent infectious diseases in elderly population.

    Target Audience
    This webinar is intended for pharmacologists, pharmacists, clinicians or graduate/postgraduate trainees wishing to better understand the implications of vaccine use among immunocompromised patient populations, with an emphasis on the elderly. Understanding practical aspects and consequences related to vaccine use among patients with reduced immune capacity for clinical practice will be discussed. This webinar is also suitable for pharmacology/biomedical graduate or medical students who are interested in immunology, clinical pharmacology or integrative medicine. Additionally, individuals who are likely to be involved in the facilitating patient care such as physician assistants, nursing and pharmacy professionals may also benefit from this webinar.

    Learning Objectives:
    Following completion of this activity, the learner will be able to:

    1. Understand changes in immune functions that take place in elderly patients: specific changes in innate and adaptive arms of immune system
    2. Discuss potential causes of immune senescence
    3. Discuss current CDC Recommended Immunization Schedule for older adults
    4. Discuss efficacy of current vaccines in aged population
    5. Discuss what needs to be done to improve immune responses to vaccination in elderly patients


    Elena Yu Enioutina, MD, PhD received her MD degree in preventive medicine and PhD in pharmacology/toxicology (immunopharmacology). Her long-standing interest in prophylaxis of infectious diseases goes back to medical school years. Immune senescence and modulation of immune responses in aged animals by cholesterol lowering drugs was topic of her PhD work. Most of her research has been focused on understanding of how modulation of the microenvironment of lymphoid and non-lymphoid organs by adjuvants can affect quality of immune responses of adult and aged animals. Dr. Enioutina investigated molecular mechanisms involved in the generation of mucosal immune responses to systemically administered antigens. She also has discovered that elevated levels and activity of myeloid derived suppressor cells is one of the mechanism responsible for inability of aged animals to properly respond to vaccination.

    UAN Number:
    Live: 0238-0000-16-046-L04-P
    On-demand:0238-0000-16-047-H04-P    Expires 11/9/2019
    ACPE 1 Contact Hours

    Knowledge Based Activity

    ACPE.jpgACPE Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.

    ACCME Logo 3.jpgACCME Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Designation Statement

    The American College of Clinical Pharmacology designates this journal CE activity for 1 AMA PRA Category 1TM credit. Physicians should only claim credit commensurate with the extent of the participation in the activity.


    In order to receive CE credit, the learner must score 75% or better on the online post-test and must complete an online evaluation.

    Speaker Disclosure:
    Dr. Elena Yu Enioutina, MD, PhD Research Assistant Professor, Clinical Pharmacology, Pediatrics, SOM, University of Utah has nothing to disclose.

    Moderators:
    Catherine Sherwin, PhD, MS, FCP and Jonathan Constance, PhD, of the University of Utah School of Medicine, who developed the continuing education portion of this activity (target audience, goals and objectives and questions with solutions) have nothing to disclose.

  • 2017 ACCP Therapeutic Dilemmas May | At The Intersection of Environmental Air Pollutant Exposure, Genetic Variation and Asthma Control

    Contains 4 Component(s), Medical Credits Offered

    ​Presented by Christopher Reilly, PhD, Associate Professor, Pharmacology and Toxicology, College of Pharmacy, University of Utah

    THERAPEUTIC DILEMMAS: At The Intersection of Environmental Air Pollutant Exposure, Genetic Variation and Asthma Control

    Wednesday, May 24, 2017; 2:00 - 3:00 PM ET

    Presented by Christopher Reilly, PhD, Associate Professor, Pharmacology and Toxicology, College of Pharmacy, University of Utah

    Why is this important to your practice?
    Air pollution is a global problem with serious health consequences. The effects of poor air quality on the efficacy of asthma control medications is of great concern for patients with respiratory disorders, their families, and healthcare providers. Exposures environmental or dietary xenobiotics are well recognized to impact drug disposition and response, such as through the induction or interactions with drug metabolizing enzymes or drug transporters. Additionally, drug responsiveness can also be modulated through receptor expression/activity within the cells lining airways. Genetic predisposition among some individuals may cause sensitization to air pollutants and interfere with the expected metabolic clearance of drugs, therefore requiring adaptation of asthma control regimens to treat more effectively an individual’s disease characteristics. This webinar will discuss new findings that connect pulmonary irritant sensing and xenobiotic clearance pathways with variations in asthma control as well as the resulting implications for treatment of asthma.

    Target Audience
    This webinar is intended for pharmacologists, pharmacists, clinicians or graduate/postgraduate trainees wishing to better understand the implications of environmental contaminants on the activity and efficacy of asthma control medication. This webinar is also suitable for pharmacology/biomedical graduate or medical students who are interested in respiratory disorders, clinical pharmacology, or integrative medicine. Additionally, individuals who are likely to be involved in facilitating patient care such as physician assistants, nursing, and pharmacy professionals may also benefit from this webinar.

    Goal and Objectives
    After completing this activity, the learner will be able to:

    1. Describe the mechanisms by which particulate matter, such as coal fly ash, can stimulate pro-inflammatory signaling cascades within the respiratory tract
    2. Discuss the potential consequences of exposure to particulate matter for those who suffer from asthma as it relates to respiratory tract physiology and medical interventions
    3. Among individuals with and without asthma, describe how genetic variation in TRP channels may predispose or influence susceptibility to inhaled particulate matter
    4. Discuss the ramifications of the findings for asthma control intervention for individuals living in different environments (i.e., different levels of exposure to particulate matter due to proximity to emissions)



    Christopher Reilly, PhD is an Associate Professor of Pharmacology and Toxicology and Associate Director of the Center for Human Toxicology at the University of Utah.  He received his PhD in Toxicology (1999) from Utah State University under Dr. Steven D. Aust. Dr. Reilly’s work focused on peroxidase- and oxygen radical-mediated toxicities and enzymatic mechanisms for iron loading and storage in ferritin. Dr. Reilly was a post-doctoral fellow from 1999-2001 at the University of Utah with Dr. Garold S. Yost and the Center for Human Toxicology where he studied mass spectrometry and catalytic mechanisms for the metabolism and bioactivation of xenobiotics by Cytochrome P450 enzymes, pulmonary-selective drug metabolism, and the pulmonary toxicity of pepper sprays. Through this work Dr. Reilly became interested in Transient Receptor Potential cation channels as mediators of xenobiotic toxicities in the lung. His work on the TRP ion channels has evolved and is now focused on interactions between TRP channels and airway inflammation and injury. His group’s work on CYP enzymes and TRP channels has fortuitously intersected leading to new insights on how genetic variations in CYPs and TRPs as well as exposure to environmental pollutants may affect asthma symptom control using traditional therapeutics.

    imageACPE Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. 

    • UAN Number:
      Live:  0238-0000-17-024-L01-P
      On Demand: 0238-0000-17-025-H01-P    Expires 5/26/2019
    • ACPE 1 Contact Hours
    • Knowledge Based Activity


    imageACCME Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

    Designation Statement
    The American College of Clinical Pharmacology designates this journal CE activity for 1 AMA PRA Category 1TM credit.  Physicians should only claim credit commensurate with the extent of the participation in the activity.

    Date of Issuance:  May 24, 2017
    Expiration Date:  May 24, 2020

    In order to receive CE credit, the learner must score 75% or better on the online post-test; complete an online evaluation and print a certificate.

    Moderators:
    Catherine Sherwin, PhD, MS, FCP and Jonathan Constance, PhD, are with the University of Utah School of Medicine.  As Moderators of the webinar. They developed the continuing education portion of this activity (target audience, goals and objectives and questions with solutions).  They have nothing to disclose.

    Presenter:
    Christopher Reilly, PhD is an Associate Professor of Pharmacology and Toxicology and Associate Director of the Center for Human Toxicology at the University of Utah and has nothing to disclose.

  • 2017 ACCP Webinars June | High Resolution Personalized Precision Therapeutics

    Contains 4 Component(s), Medical Credits Offered

    Presented by Roland Valdes Jr.​, PhD, Univ of Louisville and Keri Donaldson​, MD, PhD, Penn State Coll of Medicine and Milton S. Hershey Medical Ctr

    High Resolution Personalized Precision Therapeutics

    Wednesday, June 14, 2017; 2:00 – 3:00 PM ET 

    Presented by Roland Valdes Jr., PhD, Univ of Louisville and Keri Donaldson, MD, PhD, Penn State Coll of Medicine and Milton S. Hershey Medical Ctr

    Why is this article important to your practice?
    A growing use of medications has led to both polypharmacy and addiction. Novel technologies and pharmacogenetic tools are available to increase the precision and personalization of drug selection. We will review and demonstrate the need for novel predictive algorithms to optimize therapeutic approaches based on pharmacogenetic and related molecular diagnostic testing.   

    Target Audience
    Clinical pharmacologist providing both research and clinical practice. Practitioners of pharmacology services.

    Goal and Objectives
    After completing this activity, the learner will be able to:

    1. Define the need and availability for personalizing drug therapy using pharmacogenetics and targeted informatics tools
    2. Apply novel algorithms based on PGx-testing to increase precision of drug selection and reduce polypharmacy 
    3. Demonstrate and compare options for providing targeted selection of drugs to reduce or avoid drug addiction

    Roland Valdes Jr., PhD is a Tenured Professor of Pathology and Laboratory Medicine and of Biochemistry and Molecular Biology at the University of Louisville’s School of Medicine. He has held the appointment as Distinguished University Scholar and as Senior Vice-Chairman for the Department of Pathology. He presently serves as Chief of Clinical Chemistry and Toxicology for the University Hospital and as Director of the Clinical Chemistry Postdoctoral Fellowship Program.  Dr. Valdes received his Ph.D. in Molecular Biophysics from the University of Virginia where he also completed postdoctoral training in Biochemistry and in Clinical Chemistry and Toxicology. Prior to his move to Louisville in 1989, Dr. Valdes was on the faculty at Washington University School of Medicine in St. Louis. He is a Diplomat of the American Board of Clinical Chemistry and a Fellow of the National Academy of Clinical Biochemistry.  Dr. Valdes is nationally and internationally recognized as a leader in advancing the profession of clinical chemistry and personalized medicine through his contributions in promoting clinical chemistry as a discipline via the scholarships of clinical service, research, and teaching.  Dr. Valdes has served on numerous federal/national committees such as CLIA and NIH Study Sections, and has served as President of several key professional organizations including the Clinical Ligand Assay Society (CLAS), the National Academy of Clinical Biochemistry (NACB), the Commission for Accreditation in Clinical Chemistry (ComACC), and, most recently, the Association of Clinical Scientists (ACS).  Dr. Valdes has also served on the Board of Directors of the American Association for Clinical Chemistry (AACC) and as a Director on the American Board of Clinical Chemistry (ABCC).  He has received several distinguished scientist and recognition awards from professional organizations such as the AACC, NACB, CLAS, and ACS and has authored more than 260 publications. Dr. Valdes holds several patents and is a pioneer in establishing the application of personalized and precision medicine via laboratory diagnostics by founding the first CLIA-accredited laboratory (PGXL Laboratories) focused on providing pharmacogenetic services. He continues working on developing novel laboratory services to enable the practice of precision/personalized medicine using advanced techniques in clinical chemistry.


    Keri Donaldson, MD, PhD is Medical Director and CEO of Prescient Medicine,  His work is fueled by an extensive background in the fields of pathology, genomics, and diagnostics. An active ad hoc reviewer and consultant, Dr. Donaldson has earned a reputation as an innovative member of the medical community and garnered key positions within respected institutions and national committees. Throughout his time with Penn State College of Medicine, he’s served as Assistant Professor of Pathology (also at Hershey Medical Center), Assistant Professor of Public Health Sciences (a joint appointment also at Hershey Medical Center), Assistant Professor of Medicine, and Assistant Professor of Biochemistry. He was certified as a diplomate of both the American Board of Pathology and the National Board of Medical Examiners, and is a frequent guest speaker at regional and national symposia. Dr. Donaldson holds a BS from Pennsylvania State University, an MD from Temple University School of Medicine, and a master of science in clinical epidemiology (MSCE) from the University of Pennsylvania School of Medicine.


    Knowledge Based Activity

    ACPE Accreditation Statement

    http://accp1.inreachce.com/content/owners/accp1/images/ACPE-black.pngThe American College of Clinical Pharmacology is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. 

    UAN Number:
    Live:  0238-0000-17-029-L01-P
    On Demand: 0238-0000-17-030-H01-P

    ACPE 1 Contact Hours


    ACCME Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

    Designation Statement

    The American College of Clinical Pharmacology designates this journal CE activity for 1 AMA PRA Category 1TM credit.  Physicians should only claim credit commensurate with the extent of the participation in the activity.

    In order to receive CE credit, the learner must score 75% or better on the online post-test and must complete an online evaluation.

    Date of Issuance:  6/14/17
    Expiration Date:  6/14/20

    In order to receive CE credit, the learner must score 75% or better on the online post-test; complete an online evaluation and print a certificate.

    Roland Valdes Jr., PhD, Professor, Univ of Louisville School of Medicine discloses that he receives consulting fees from PGXL Laboratories for being member of the Board of Directors and Univ of Louisville receives Grants from PGXL Laboratories.

  • 2017 ACCP Therapeutic Dilemmas July | How to Get Targeted Agents to the Patients Who Need Them

    Contains 4 Component(s), Medical Credits Offered

    Presented by Joanna Yi, MD, Assistant Professor of Pediatric Hematology/Oncology, Baylor College of Medicine/ Texas Children’s Cancer and Hematology Centers

    THERAPEUTIC DILEMMAS: How to Get Targeted Agents to the Patients Who Need Them.  

    Tuesday, July 11th 2017; 2:00 – 3:00 pm ET

    Presented by Joanna Yi, MD, Assistant Professor of Pediatric Hematology/Oncology, Baylor College of Medicine/ Texas Children’s Cancer and Hematology Centers 

    Why is this topic important to your practice?
    Since the discovery of molecularly targeted agents such as Imatinib, there has been an ever-increasing drive to identify other targeted therapeutics to treat patients with more efficacy and less toxicity.  With the advent of genomic sequencing and more recently other "omics" technologies however, the information known about a patient's tumor has outstripped the physician's ability to prescribe medications precisely targeting all the known "drivers" of that disease. Precision medicine efforts to better match patients with targeted agents and innovative trial designs are underway and will be reviewed. Additionally, other methods to expedite and maximize the translation of targeted agents to patients will be addressed.  This will be illustrated with specific examples, including those from pediatric oncology.

    Target Audience
    This webinar is intended for pharmacologists, pharmacists, clinicians or graduate/postgraduate trainees wishing to better understand current developments in oncology to match patients with the appropriate molecularly targeted therapeutic agents and innovative trial designs with an emphasis on pediatric malignancies. This webinar is also suitable for pharmacology/biomedical graduate or medical students who are interested in oncology, clinical pharmacology or integrative medicine. Additionally, individuals who are likely to be involved in the facilitating patient care such as physician assistants, nursing and pharmacy professionals may also benefit from this webinar.

    Goal and Objectives After completing this activity, the learner will be able to:

    1. Identify obstacles blocking the translation of therapeutics in the lab to clinical trials
    2. List several strategies to accelerate the translation of therapeutics to clinical trials
    3. List reasons why pediatric drug discovery uniquely slower than desired
    4. Identify strategies which may aid in mitigating the development of resistance to targeted therapy

    Joanna Yi, MD, is an assistant professor of Pediatric Hematology/Oncology at Baylor College of Medicine/ Texas Children’s Cancer and Hematology Centers.  She completed her pediatric hematology/oncology fellowship at Dana-Farber/Boston Children’s Cancer and Hematology Centers, where she trained in the laboratory of James Bradner in epigenetics and chemical biology, focusing on the development of DOT1L inhibitors and BET bromodomain inhibitors.  She is a member of the Center for Drug Discovery at BCM, where she seeks to develop and translate targeted small molecules for challenging pediatric cancers. She serves as an intermediary between Texas Children’s Cancer Center labs to champion targets of interest through the drug screening platforms available at the Center for Drug Discovery, including the DNA-Encoded Technology platform.  Her lab has a specific interest chromatin-modifying small molecules, identifying and assessing top synergistic combinations for development pre-clinically and eventually clinically, and concurrently developing the necessary pharmacodynamics biomarkers for translation of these agents.   She is a member of the Developmental Therapeutics, Leukemia, and Neuroblastoma teams at Texas Children’s, and she will be chairing a first-in-children trial of a BET bromodomain inhibitor through the Children’s Oncology Group.

    image

    ACPE Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. 

    ACPE 1 Contact Hours 

    UAN Number: Live:  0238-0000-17-035-L05-P 

    UAN Number: On-demand: 0238-0000-17-036-H05-P 

    Knowledge Based Activity


    image

    ACCME Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

    Designation Statement

    The American College of Clinical Pharmacology designates this journal CE activity for 1 AMA PRA Category 1TM credit.  Physicians should only claim credit commensurate with the extent of the participation in the activity.

    In order to receive CE credit, the learner must score 75% or better on the online post-test and must complete an online evaluation.


     

    Date of Issuance:  July 11, 2017
    Expiration Date:  July 11, 2020

  • 2018 ACCP Virtual Journal Club February | Pharmacokinetic Study of Intravenous Acetaminophen Administered to Critically Ill Multiple-Trauma Patients at the Usual Dosage and a New Proposal for Administration

    Contains 5 Component(s), Medical Credits Offered

    Presented by: Manuel Gerónimo-Pardo, MD, PhD, Department of Anesthesiology, Complejo Hospitalario Universitario of Albacete, Spain. This article addresses a new dose form and therapeutic application of acetaminophen in multi-trauma patients.

    ACCP Virtual Journal Club - 2018 Feb - Pharmacokinetic Study of Intravenous Acetaminophen Administered to Critically Ill Multiple-Trauma Patients at the Usual Dosage and a New Proposal for Administration

    Live webinar with the author: February 21, 2018   2:00 – 3:00 PM EST  

    On-demand webinar recording:  February 28, 2018 to February 28, 2021

    Why is this article important to your practice? 

    This article addresses a new dose form and therapeutic application of acetaminophen in multi-trauma patients. 

    Target Audience: Physicians, Pharmacists, and other clinicians involved in treating multi-trauma patients. 

    Goal and Objectives - After completing this activity, the learner will be able to:

    • Describe three potential clinical benefits of acetaminophen in the critically ill patient.
    • List the primary hepatic metabolic routes and the reported renal clearance of acetaminophen.
    • Describe the serum concentrations of acetaminophen needed to provide an antipyretic effect and analgesia.
    • Compare the total daily dose of acetaminophen needed to maintain a serum concentration of 10 ug/ml using multiple dosing and a continuous infusion.  

    To receive full credit, learners must pre-read the article located in the "handouts" tab.

    See Continuing Education Information in the "handouts" tab for more details.


  • 2018 ACCP Webinar June | How to be a Great Journal Peer Reviewer

    Contains 4 Component(s), Medical Credits Offered

    Presented by: Joseph S. Bertino Jr., PharmD, FCP, FCCP, Editor-in-Chief, The Journal of Clinical Pharmacology and David J. Greenblatt MD, FCP, Editor-in-Chief Clinical Pharmacology in Drug Development. This webinar provides professional training on performing scientific journal manuscript peer reviews.

    ACCP 2018 Webinar - How to be a GREAT Journal Peer Reviewer

    Live webinar with the Editor-in-Chiefs: June 13, 2018   2:00 – 3:00 PM ET  

    On-demand webinar recording:  June 13, 2018 to June 13, 2021

    Why is this article important to your practice? 

    At the completion of this webinar participants will have a strong understanding and the skills to properly review a scientific manuscript, a professional competency applicable to journal peer reviewing across professions. Topics to be covered include: why one should serve as peer reviewer; the purpose of manuscript reviews; aspects of a great review; when to decline a review; confidentiality; a technical guide for reviews for each section of the manuscript; and writing the review.  

    Target Audience: 

    Researchers, Physicians, Pharmacists, and other professionals requiring training in the professional competencies of peer reviewing. 

    Learning Objectives: 

    After completing this activity, the learner will be able to:

    1. Describe why the peer review process is important;
    2. Explain how to review various sections of a scientific manuscript;
    3. Identify elements of writing a review that will be of benefit to the authors and to the Editor of the Journal.

    To receive full credit, learners must attend the complete live webinar or view the complete on-demand webinar; pass a post-course assessment with 75% or greater and complete an evaluation.


  • 2018 ACCP Virtual Journal Club August | Evaluation of Flexible Tacrolimus Drug Concentration Monitoring Approach in Patients Receiving Extended‐Release Once‐Daily Tacrolimus Tablets

    Contains 5 Component(s), Medical Credits Offered Recorded On: 04/15/2019

    Presented by: Timothy Horwedel, MHA, PharmD, BCPS and Patricia West-Thielke, PharmD. This webinar will assist learners to evaluate and apply a flexible tacrolimus concentration monitoring approach in the management of kidney transplant patients receiving extended-release once-daily tacrolimus tablets that allows for an extended therapeutic monitoring window based upon utilization of formulas and tools for interpreting drug levels within the expanded window.

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    Attendees Obtain Free CE Credits from ACCP Virtual Journal webinars!

    Evaluation of Flexible Tacrolimus Drug Concentration Monitoring Approach in Patients Receiving Extended&dash;Release Once&dash;Daily Tacrolimus Tablets

    ACCP 2018 Virtual Journal Club Webinars

    Live Session: Wednesday, August 8, 2018 from 2:00pm to 3:00pm ET

    On Demand: August 8, 2018 to August 8, 2021

    Why is this webinar important to you? 

    Learners that complete this course will be able to evaluate and apply a flexible tacrolimus concentration monitoring approach in the management of kidney transplant patients receiving extended&dash;release once&dash;daily tacrolimus tablets that allows for an extended therapeutic monitoring window based upon utilization of formulas and tools for interpreting drug levels within the expanded window.


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    ACPE Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.

    UAN: 0238-0000-18-035-L/H01-P– ACPE 1 Contact Hours

    Activity Type:  Knowledge-based   Format: Live & Home-study   Target Audience: ‘P’

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    ACCME Accreditation Statement

    The American College of Clinical Pharmacology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. 

    ACCME Designation Statement

    The Accreditation Council for Continuing Medical Education designates this live and enduring CE activity for 1 AMA PRA Category 1TM credit. Physicians should only claim credit commensurate with the extent of their participation in the activity.


    Target Audience

    Interprofessional team of Physicians, Pharmacists, PhDs, Nurse Practitioners and Physician Assistants.

    Learning Objectives

    After completing this activity, the learner will be able to:

    • Compare the different pharmacokinetic profiles of immediate release and extended-release once-daily tacrolimus formulations;
    • Describe the correlations between tacrolimus concentrations around trough levels and the overall exposure (plasma drug concentration curve/AUC) over a dosing interval;
    • Interpret non-standard tacrolimus concentration monitoring results and apply these approaches to dosage monitoring/adjustments plans in patients.

    Requirements to Receive Credit

    In order to receive CE credit, the learner must register for the educational activity, study the provided journal article, attend the Live webinar or view the on-demand webinar, complete the online learning self-assessment (post-test), complete the online course evaluation and print the certificate.

    Disclosures: 

    • Author/Faculty:   Timothy Horwedel, MHA, PharmD, BCPS, Transplant Clinical Specialist, Barnes-Jewish Hosp, Dept of Pharmacy, reports a relevant financial relationship (honoraria, grant support) with Veloxis Pharmaceuticals. An independent content review has been completed which finds the article and presentation to be evidence-based, unbiased and non-promotional in nature.
    • Author/Faculty:   Patricia West-Thielke, PharmD, Director of Clinical Transplant Research, Univ of Illinois, Dept of Surgery, reports relevant financial relationships (honoraria, grant support) with Veloxis Pharmaceuticals and Astellas Pharma US. An independent content review has been completed which finds the article and presentation to be evidence-based, unbiased and non-promotional in nature.
    • Moderator/CE Planner:  Parag Kumar, PharmD, Associate Director Clinical Pharmacology, Otsuka America Pharmaceuticals, has nothing to disclose related to this topic.
    • CE Content Reviewer:   Sandeep Kushal, MBBS, MD, Professor and Head, Dayanand Medical College and Hosp, Dept of Pharmacology, has nothing to disclose.

    Schedule & Fees

    The ACCP webinar programs occur several times per year. Registration for the webinars are required but are free of charge to all learners.

    Acknowledgement of Financial Support

    No financial support was received for this educational activity.

    Home Study Initial Release and Expiration Dates

    Date of Issuance: August 8, 2018

    Expiration Date: August 8, 2021

    Online Location: https://accp1.org/Members/Cont...


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    Timothy Horwedel, MHA, PharmD, BCPS

    Clinical Pharmacy Specialist, Barnes-Jewish Hosp

    Timothy Horwedel, MHA, PharmD, BCPS, received his PharmD from Northeastern Univ in 2008, then completed a PGY1 residency at Henry Ford Hosp, followed by a PGY2 in Solid Organ Transplantation at Barnes-Jewish Hosp. Following training, he served first as a clinical specialist in liver, kidney, and pancreas transplant from 2010 – 2012 at Univ of Michigan. Since 2012, he has been a clinical specialist in liver, kidney, and pancreas transplant at Barnes-Jewish Hosp, as well as serving as transplant supervisor and PGY1 residency program director. He holds an appointment of Adjunct Experiential Assistant Professor with the St. Louis Coll of Pharmacy as well as an appointment as an Adjunct Instructor with Washington Univ School of Medicine.

    Patricia West-Thielke, PharmD

    Director of Clinical Transplant Research, Univ of Illinois, Dept of Surgery

    Dr. Patricia West-Thielke, PharmD, is the Director of Clinical Transplant Research and Research Assistant Professor of Surgery at the Univ of Illinois Hosp and Health Sciences System. She has  been the principal investigator for over 30 kidney transplant clinical trials and manages a clinical trials unit. She is actively involved with the transplant program educating patients in both the pre- and post-transplant phases. Her areas of research include adherence, pharmacokinetics and sensitization .